Twisted Sisters takes viewers inside the most shocking crimes ever committed by the unlikeliest of pairs. Sometimes these sisters work together to commit a crime, but often the duo can turn against one another with the deadliest of outcomes. The series interviews immediate family members and close friends to learn what triggered the sisters' path towards a life of crime. Investigators and law enforcement anchor each story as they recount firsthand their unraveling of the case and try to make sense of the crimes committed.